We study the evolutionary genetic basis of life history, in particular ageing and reproduction. Using a combination of functional genetic approaches and -omics, we aim study how genomic polymorphisms that persist in natural populations affect gene regulatory networks, physiology, and ultimately fitness.
Drosophila melanogaster, Nasonia vitripennis
- Functional genetics (RNAi, CRISPR-Cas9, recombinant outbred populations)
- Population genomics (PoolSeq), experimental evolution (Evolve & resequence)
- Gene expression analyses (RNAseq, RT-qPCR)
- Fluorescent microscopy, microdissection and immunostaining
- Life history assays (lifespan, reproduction, development time, viability, body size, starvation resistance, oxidative stress resistance, fat content)
- Behavioural assays (foraging, learning ability, activity)