1) how do morphogens regulate patterns of cellular metabolic and mechanical properties in tissue? 2) how does tissue size and shape emerge from the collective interactions of these constituent cells? 3) how do molecular, cellular and tissue-scale processes remain coordinated at different temperatures? 4) how do Drosophila acclimate to different temperatures in the lab and in the wild?
Genetics, lipidomics, cell biology, biochemistry, biophysics, long term time lapse imaging, quantitative image analysis, modeling.